An abstract titled, “Estrogen exposure from modern contraceptives and vascular risk in women with migraine: A nationwide electronic medical record database study,” was published in Cephalalgia by authors Keiko Ihara, C William Pike, Gavin Hui, Saurabh Gombar, Michael L Jackson, Alison Callahan, Gretchen E Tietjen, and Chia-Chun Chiang. The authors are affiliated with Mayo Clinic, Stanford University, University of Toledo, and Atropos Health.
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Many guidelines list migraine with aura (MwA) as a contraindication to estrogen-containing combined hormonal contraceptives (CHCs) due to vascular risks. However, current evidence is based on small sample studies with potential influence by confounding factors. Additionally, few studies have examined the vascular risk associated with modern CHCs with lower dose estrogen, particularly in relation to aura status. The present study aims to investigate the vascular risk of modern CHCs in women with migraine with and without aura.