An abstract titled “Comparative Risk of New-Onset Autoimmune Disease Following COVID-19 mRNA versus DNA Vaccination: A Propensity-Matched Cohort Study Using the Epic Cosmos Database” was presented at the SID Annual Meeting by authors Nethra Srinivasan, William Pike, Mike Jackson, Kavita Sarin. The authors are affiliated with Stanford University School of Medicine; University of California Berkeley School of Public Health, and Atropos Health.
Short Summary: Concerns about autoimmune disease following COVID-19 vaccination persist, yet few studies have directly compared autoimmune risk between vaccine platforms. Using data from the Epic Cosmos and the Atropos Evidence™ Network, researchers conducted a propensity-matched retrospective cohort study to evaluate whether mRNA vaccines differ from DNA-based vaccines in the incidence of new-onset autoimmune conditions among adults without prior autoimmune disease. Findings suggest a trend toward higher autoimmune disease risk with mRNA vaccination, with notable differences in autoimmune dermatologic conditions, supporting the need for further investigation.